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Title: Molecular heterogeneity of blaVIM-2-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-β-lactamase
Author, co-author: Pallecchi, L.; Riccio, M. L.; Docquier, Jean-Denis; Fontana, R.; Rossolini, G. M.
Abstract: A blaVIM-2 metallo-β-lactamase determinant, identical to that previously identified in Pseudomonas aeruginosa COL-1 isolate from a French hospital, was detected on a 28-kb plasmid carried by a nosocomial isolate of P. aeruginosa from Verona, Italy. In this plasmid the blaVIM-2 determinant was inserted into a class 1 integron of original structure, named In72, that contains a partially deleted intI1 integrase gene and two gene cassettes. The first cassette carries an aacA4 aminoglycoside acetyl transferase determinant. The second cassette carries a blaVIM-2 determinant followed by a partially deleted attC site. The structure of In72 was notably different from that of In56, the blaVIM-2-containing integron found in the COL-1 isolate, revealing the existence of molecular heterogeneity among blaVIM-2-containing integrons in clinical isolates of P. aeruginosa from Europe. © 2001 Federation of European Microbiological Societies.
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Molecular heterogeneity of blaVIM-2-containing integrons from Pseudomonas aeruginosa plasmids encoding the VIM-2 metallo-β-lactamase
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Keywords :
[en] Metallo-β-lactamase ; Plasmid ; Pseudomonas aeruginosa ; Acetyltransferases ; Amino Acid Sequence ; Base Sequence ; DNA Transposable Elements ; Integrases ; Molecular Sequence Data ; Plasmids ; Recombination, Genetic ; Pseudomonas
Abstract :
[en] A blaVIM-2 metallo-β-lactamase determinant, identical to that previously identified in Pseudomonas aeruginosa COL-1 isolate from a French hospital, was detected on a 28-kb plasmid carried by a nosocomial isolate of P. aeruginosa from Verona, Italy. In this plasmid the blaVIM-2 determinant was inserted into a class 1 integron of original structure, named In72, that contains a partially deleted intI1 integrase gene and two gene cassettes. The first cassette carries an aacA4 aminoglycoside acetyl transferase determinant. The second cassette carries a blaVIM-2 determinant followed by a partially deleted attC site. The structure of In72 was notably different from that of In56, the blaVIM-2-containing integron found in the COL-1 isolate, revealing the existence of molecular heterogeneity among blaVIM-2-containing integrons in clinical isolates of P. aeruginosa from Europe. © 2001 Federation of European Microbiological Societies.
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