Title: BEL-2, an extended-spectrum β-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa
Author, co-author: Poirel, L.; Docquier, Jean-Denis; De Luca, F.; Verlinde, A.; Ide, L.; Rossolini, G. M.; Nordmann, P.
Abstract: A Pseudomonas aeruginosa isolate recovered in Belgium produced a novel extended-spectrum ß-lactamase, BEL-2, differing from BEL-1 by a single Leu162Phe substitution. That modification significantly altered the kinetic properties of the enzyme, increasing its affinity for expanded-spectrum cephalosporins. The blaBEL-2 gene was identified from a P. aeruginosa isolate clonally related to another blaBEL-1-positive isolate. Copyright © 2010, American Society for Microbiology. All Rights Reserved.

BEL-2, an extended-spectrum β-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa
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[en] Pseudomonas aeruginosa ; Belgium ; Cephalosporinase ; Cephalosporins ; Cross Infection ; Escherichia coli ; Genes, Bacterial ; Humans ; Kinetics ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa ; Pseudomonas Infections
Abstract :
[en] A Pseudomonas aeruginosa isolate recovered in Belgium produced a novel extended-spectrum ß-lactamase, BEL-2, differing from BEL-1 by a single Leu162Phe substitution. That modification significantly altered the kinetic properties of the enzyme, increasing its affinity for expanded-spectrum cephalosporins. The blaBEL-2 gene was identified from a P. aeruginosa isolate clonally related to another blaBEL-1-positive isolate. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
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