Mechanical Forces Orchestrate Brain Development.
11 января 2021 года
16:48
Mechanical Forces Orchestrate Brain Development.
Текст новости:
Title: Mechanical Forces Orchestrate Brain Development.
Author, co-author: Javier-Torrent, Míriam; Zimmer-Bensch, Geraldine; Nguyen, Laurent
Abstract: During brain development, progenitors generate successive waves of neurons that populate distinct cerebral regions, where they settle and differentiate within layers or nuclei. While migrating and differentiating, neurons are subjected to mechanical forces arising from the extracellular matrix, and their interaction with neighboring cells. Changes in brain biomechanical properties, during its formation or aging, are converted in neural cells by mechanotransduction into intracellular signals that control key neurobiological processes. Here, we summarize recent findings that support the contribution of mechanobiology to neurodevelopment, with focus on the cerebral cortex. Also discussed are the existing toolbox and emerging technologies made available to assess and manipulate the physical properties of neurons and their environment.
Commentary: Copyright © 2020 Elsevier Ltd. All rights reserved.

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Текст со страницы (автоматическое получение):
Abstract :
[en] During brain development, progenitors generate successive waves of neurons that populate distinct cerebral regions, where they settle and differentiate within layers or nuclei. While migrating and differentiating, neurons are subjected to mechanical forces arising from the extracellular matrix, and their interaction with neighboring cells. Changes in brain biomechanical properties, during its formation or aging, are converted in neural cells by mechanotransduction into intracellular signals that control key neurobiological processes. Here, we summarize recent findings that support the contribution of mechanobiology to neurodevelopment, with focus on the cerebral cortex. Also discussed are the existing toolbox and emerging technologies made available to assess and manipulate the physical properties of neurons and their environment.
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Автоматическая система мониторинга и отбора информации
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