Tetracationic porphyrin derivatives against human breast cancer
25 сентября 2021 года
14:18
Tetracationic porphyrin derivatives against human breast cancer
Текст новости:
Title: Tetracationic porphyrin derivatives against human breast cancer
Author, co-author: Gamelas, Sara; Moura, Nuno; Habraken, Yvette; Piette, Jacques; Neves, Maria; Faustino, Maria
Abstract: Photodynamic therapy (PDT) is an alternative to conventional chemotherapy for the treatment of several types of cancer. Its advantages are reduced side effects and development of resistance mechanisms. In this work, we evaluated the photosensitization capabilities of 5,10,15,20-tetrakis[4-(pyridinium-1-yl-methyl)phenyl]porphyrin, its N-confused isomer and tow if its neutral precursors. The results were compared with the ones obtained with the cationic 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP) used as positive control. Both regular porphyrin derivatives showed higher efficiency to generate singlet oxygen than TMPyP. Next, we demonstrated that one of the cationic porphyrin is an efficient photosentitizer kills MCF7 breast cancer cells. The study of the cell death mechanisms induced by the photodynamic process showed that 5,10,15,20-tetrakis[4-(pyridinium-1-yl-methyl)phenyl]porphyrin and TMPyP caused cell death by autophagic flux and necrosis.

Связанные объекты: #PDT (найти в новостях).

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Tetracationic porphyrin derivatives against human breast cancer
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[en] Photodynamic therapy (PDT) is an alternative to conventional chemotherapy for the treatment of several types of cancer. Its advantages are reduced side effects and development of resistance mechanisms. In this work, we evaluated the photosensitization capabilities of 5,10,15,20-tetrakis[4-(pyridinium-1-yl-methyl)phenyl]porphyrin, its N-confused isomer and tow if its neutral precursors. The results were compared with the ones obtained with the cationic 5,10,15,20-tetrakis(1-methylpyridinium-4-yl)porphyrin (TMPyP) used as positive control. Both regular porphyrin derivatives showed higher efficiency to generate singlet oxygen than TMPyP. Next, we demonstrated that one of the cationic porphyrin is an efficient photosentitizer kills MCF7 breast cancer cells. The study of the cell death mechanisms induced by the photodynamic process showed that 5,10,15,20-tetrakis[4-(pyridinium-1-yl-methyl)phenyl]porphyrin and TMPyP caused cell death by autophagic flux and necrosis.
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